Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma.

Does Nitric Oxide Generated by Dendritic Cells Contribute to the Low Incidence of GVHD after Cord Blood Transplantation?

TLR agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response

Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. Objective: To improve the efficacy of dendritic ce...

Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model

Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...

افزایش کارایی سلول‌های دندریتیک اجزای پروتئینی در مقایسه با عصاره تام لیستریامونوسایتوژنز در ایمونوتراپی مدل تجربی تومور

Background and Objective: Using dendritic cells (DCs) loaded with tumor antigens as a therapeutic strategy against tumors has been proposed. In order to increase the efficacy of DCs, a variety of factors such as TLR ligand molecules and bacterial products are used. In this study, the protein components of the bacteria Listeria monocytogeneses (LM) for induction of dendritic cell maturation were...

القای سلول‌های دندریتیک تولروژن موشی با تنظیم کاهشی ملکول کمک تحریکی CD40 با استفاده از وکتور لنتی ویروس

Induction of Tolerogenic Murine Dendritic Cells by Downregulating the Co-stimulatory Molecule of CD40 Using Lentivirus Vector Mahmoodzadeh A1, Pourfatollah AA1, Karimi MH2, Moazzeni SM1 1Dept. of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2Transplantation Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Correspond Aut...